Abstract: The paper presents readily implementable approaches for fault detection and diagnosis (FDD) based on measurements from multiple sensor groups, for industrial systems. Specifically, the use of hierarchical clustering (HC) and self-organizing map neural networks (SOMNNs) are shown to provide robust and user-friendly tools for application to industrial gas turbine (IGT) systems. HC fingerprints are found for normal operation, and FDD is achieved by monitoring cluster changes occurring in the resulting dendrograms. Similarly, fingerprints of operational behaviour are also obtained using SOMNN based classification maps (CMs) that are initially determined during normal operation, and FDD is performed by detecting changes in their CMs. The proposed methods are shown to be capable of FDD from a large group of sensors that measure a variety of physical quantities. A key feature of the paper is the development of techniques to accommodate transient system operation, which can often lead to false-alarms being triggered when using traditional techniques if the monitoring algorithms are not first desensitized. Case studies showing the efficacy of the techniques for detecting sensor faults, bearing tilt pad wear and early stage pre-chamber burnout, are included. The presented techniques are now being applied operationally and monitoring IGTs in various regions of the world.